Straumann® SLActive®

Para além da hidrofilia — a ciência do alto desempenho

Nanoestruturas diferentes presentes na superfície SLActive®27,28

As diferentes nanoestruturas descobertas na superfície SLActive® provam que a topografia da superfície SLActive® difere da superfície SLA®.

Roxolid® SLA®

Roxolid® SLActive®

As nanoestruturas na SLActive® aumentam a área da superfície em mais de 50%25

Aumento da área da superfície do implante: +50% do que a Roxolid® SLA®.

Como maximizar a sua superfície de implante?

  • Área maior de superfície em contacto com o osso melhora o BIC*32
  • A microrrugosidade da SLA®/SLActive® aumenta a área de superfície em pelo menos 100%, comparativamente com a superfície maquinada26
  • Além disso, as nanoestruturas aumentam a área de superfície SLActive® em mais de 50%25

*BIC = contacto entre o osso e o implante

A investigação in-vitro avançada demonstra que as nanoestruturas promovem a osteointegração precoce23,24

Formação acrescida de rede de fibrina sobre a SLActive® com nanoestruturas.23,24 Imagem de microscopia eletrónica de formação de rede de fibrina sobre a Roxolid® SLActive® (15 min de incubação com sangue humano integral).*

Superfície Roxolid® SLActive® sem nanoestruturas**

Superfície Roxolid® SLActive® com nanoestruturas

As mais recentes pesquisas in-vitro sugerem que a hidrofilia não explica por si só a osteointegração acelerada associada às propriedades da superfície SLActive® . Novos dados indicam que as nanoestruturas da superfície SLActive® promovem a formação da rede de fibrina e a mineralização, facilitando assim as primeiras fases da osteointegração. Na verdade, a SLActive® com nanoestruturas mostra um nível mais elevado de formação de rede de fibrina e de mineralização de células ósseas, quando comparada com a SLActive® sem nanoestruturas (in vitro).23,24

* Empa, Laboratórios Federais Suíços para Ciência e Tecnologia de Materiais. www.empa.ch
** Superfície experimental para estudar o efeito das nanoestruturas

Mineralização mais elevada de células ósseas na SLActive® com nanoestrutura23,24

Mineralização de células ósseas humanas medida após 28 dias de colocação sobre superfícies incubadas em sangue. Resumo das concentrações de Ca2+ no final da cultura em função da superfície.*

* Empa, Laboratórios Federais Suíços para Ciência e Tecnologia de Materiais. www.empa.ch
** Superfície experimental para estudar o efeito das nanoestruturas

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Referências

1 Comparação de implantes Straumann SLActive com implantes Straumann SLA. Lang NP, Salvi GE, Huynh-Ba G, Ivanovski S, Donos N, Bosshardt DD. Early osseointegration to hydrophilic and hydrophobic implant surfaces in humans. Clin Oral Implants Res. 2011 Apr;22(4):349-56. doi: 10.1111/j.1600-0501.2011.02172.x; Rupp F, Scheideler L, Olshanska N, de Wild M, Wieland M, Geis-Gerstorfer J. Enhancing surface free energy and hydrophilicity through chemical modification of microstructured titanium implant surfaces. Journal of Biomedical Materials Research A, 76(2):323-334, 2006. ; De Wild M. Superhydrophilic SLActive® implants. Straumann document 151.52, 2005 ; Katharina Maniura. Laboratory for Materials – Biology Interactions Empa, St. Gallen, Switzerland Protein and blood adsorption on Ti and TiZr implants as a model for osseointegration. EAO 22nd Annual Scientific Meeting, October 17 – 19 2013, Dublin ; Schwarz, F., et al., Bone regeneration in dehiscence-type defects at non-submerged and submerged chemically modified (SLActive®) and conventional SLA® titanium implants: an immunohistochemical study in dogs. J Clin.Periodontol. 35.1 (2008): 64–75. ; Rausch-fan X, Qu Z, Wieland M, Matejka M, Schedle A. Differentiation and cytokine synthesis of human alveolar osteoblasts compared to osteoblast-like cells (MG63) in response to titanium surfaces. Dental Materials 2008 Jan;24(1):102-10. Epub 2007 Apr 27. ; Schwarz F, Herten M, Sager M, Wieland M, Dard M, Becker J. Histological and immunohistochemical analysis of initial and early osseous integration at chemically modified and conventional SLA® titanium implants: Preliminary results of a pilot study in dogs. Clinical Oral Implants Research, 11(4): 481-488, 2007. Raghavendra S, Wood MC, Taylor TD. Int. J. Oral Maxillofac. Implants. 2005 May–Jun;20(3):425–31. 9 Oates TW, Valderrama P, Bischof M, Nedir R, Jones A, Simpson J, Toutenburg H, Cochran DL. Enhanced implant stability with a chemically modified SLA® surface: a randomized pilot study. Int. J. Oral Maxillofac. Implants. 2007;22(5):755–760.
2 Nicolau P, Guerra F, Reis R, Krafft T, Benz K, Jackowski J. 10-year outcomes with immediate and early loaded implants with a chemically modified SLA surface. Quintessence Int. 2018 Dec 18:2-12.
3 Patients treated with dental implants after surgery and radio-chemotherapy of oral cancer. Heberer S, Kilic S, Hossamo J, Raguse J-D, Nelson K. Rehabilitation of irradiated patients with modified and conventional sandblasted, acid-etched implants: preliminary results of a split-mouth study. Clin. Oral Impl. Res. 22, 2011; 546–551.
4 Yerit, K., Posch, M., Seemann, M., Hainich, S., Dortbudak, O., Turhani, D., Ozyuvaci, H., Watzinger, R. and Ewers, R. (2006) Implant Survival in Mandibles of Irradiated Oral Cancer Patients. Clinical Oral Implants Research, 17, 337-344. http://dx.doi.org/10.1111/j.1600-0501.2005.01160.x.
5 Verdonck, H.W.D., Meijer, G.J., Laurin, T., Nieman, F.H.M., Stoll, C., Riediger, D., Stoelinga, P.J.W. and de Baat, C. (2007) Assessment of Vascularity in Irradiated and Non-Irradiated Maxillary and Mandibular Alveolar Minipig Bone Using Laser Doppler Flowmetry. International Journal of Oral Maxillofacial Implants, 22, 774-778.
6 Hu, W.W., Ward, B.B., Wang, Z. and Krebsbach, P.H. (2010) Bone Regeneration in Defects Compromised by Radiotherapy. Journal of Dental Research, 89, 77-81. http://dx.doi.org/10.1177/0022034509352151.
7 Wang, R., Pillai, K. and Jones, P.K. (1998) Dosimetric Measurements of Scatter Radiation from Dental Implants in Stimulated Head and Neck Radiotherapy. International Journal of Oral Maxillofacial Implants, 13, 197-203.
8 Grotz, K.A., Al-Nawas, B., Piepkorn, B., Reichert, T.E., Duschner, H. and Wagner, W.(1999) Micromorphological Findings in Jaw Bone after Radiotherapy. Mund-, Kiefer- und Gesichtschirurgie, 3, 140-145.
9 Chambrone L, Mandia J, Shibli JA, Romito GA, Abrahao M. Dental Implants Installed in Irradiated Jaws: A Systematic Review. Journal of Dental Research. 2013;92(12 Suppl):119S-130S. doi:10.1177/0022034513504947.
10 Shugaa-Addin B, Al-Shamiri H-M, Al-Maweri S, Tarakji B. The effect of radiotherapy on survival of dental implants in head and neck cancer patients. Journal of Clinical and Experimental Dentistry. 2016;8(2):e194-e200. doi:10.4317/jced.52346.
11 Nooh N. Dental implant survival in irradiated oral cancer patients: a systematic review of the literature. Int J Oral Maxillofac Implants. 2013 Sep-Oct;28(5):1233-42. doi: 10.11607/jomi.3045.
12 Dholam KP, Gurav SV. Dental implants in irradiated jaws: A literature review. J Can Res Ther [serial online] 2012 [cited 2016 Aug 17];8:85-93. Available from: http://www.cancerjournal.net/text.asp?2012/8/6/85/92220.
13 Nelson, K., Stricker, A., Raguse, J.-D. and Nahles, S. (2016), Rehabilitation of irradiated patients with chemically modified and conventional SLA implants: a clinical clarification. J Oral Rehabil, 43: 871–872. doi:10.1111/joor.12434
14 C. NACK, J.-D. RAGUSE, A. STRICKER , K. NELSON & S. NAHLES. Rehabilitation of irradiated patients with chemically modified and conventional SLA implants: five-year follow-up. Journal of Oral Rehabilitation 2015 42; 57—64.
15 Devlin H, Garland H, Sloan P. Healing of tooth extraction sockets in experimental diabetes mellitus. J. of Oral Maxillofac. Surg. 1996; 54:1087-1091
16 Wang F1, Song YL, Li DH, Li CX, Wang Y, Zhang N, Wang BG. Type 2 diabetes mellitus impairs bone healing of dental implants in GK rats. Diabetes Res Clin Pract. 2010; 88:e7-9.
17 IDF Diabetes Atlas, 7th Edition, 2015 http://www.diabetesatlas.org/.
18 US Centers for Disease Control and Prevention. Diabetes 2014 report card. Available from: www.cdc.gov/diabetes/library/reports/congress.html. Accessed September 2015.
19 Cabrera-Domínguez JJ et al. Clinical performance of titanium-zirconium implants with a hydrophilic surface in patients with controlled type 2 diabetes mellitus: 2-year results from a prospective case-control clinical study Clin Oral Investig 2020 Jul;24(7):2477-2486
20 Hotchkiss KM, Ayad NB, Hyzy SL, Boyan BD, Olivares-Navarrete R. Dental implant surface chemistry and energy alter macrophage activation in vitro. Clin. Oral Impl. Res. 00, 2016, 1–10. doi: 10.1111/clr.12814.
21 Lee R, Hamlet SM, Ivanovski S. The influence of titanium surface characteristics on macrophage phenotype polarization during osseous healing in type I diabetic rats: A pilot study. Clin Oral Impl Res (accepted 4/8/2016).
22 El Chaar E, Zhang L, Zhou Y, et al. Osseointegration of Superhydrophilic Implants Placed in Defect Grafted Bones. International Journal of Oral & Maxillofacial Implants . Mar/Apr2019, Vol. 34 Issue 2, p443-450
23 Müller E, Rottmar M, Guimond S, Tobler U, Stephan M, Berner S, Maniura K The interplay of surface chemistry and (nano-)topography defines the osseointegrative potential of Roxolid® dental implant surfaces. eCM Meeting Abstracts 2017, Collection 3; SSB+RM (page 31).
24 EMPA (2017) Report additional experiments: Impact of RXD SLA, RXD SLAnano, RXD SLActive, and RXD pmod SLA surfaces on protein adsorption, blood coagulation, and osteogenic differentiation of HBCs. Final report: Impact of RXD SLA, RXD SLAnano, RXD SLActive, and RXD pmod SLA surfaces on protein adsorption, blood coagulation, and osteogenic differentiation of HBCs. EMPA, Swiss Federal Laboratories for Materials Science and Technology (data on file).
25 Stavropoulos A et al. Greater Osseointegration Potential with Nanostructured Surfaces on TiZr: Accelerated vs. Real-Time Ageing. Materials (Basel). 2021 Mar 29;14(7):1678.
26 Wennerberg A, Albrektsson T. On implant surfaces: a review of current knowledge and opinions. Int J Oral maxillofac Implants 2009: 24:63-74
27 Kopf BS, Ruch S, Berner S, Spencer ND, Maniura-Weber K. 2015. The role of nanostructures and hydrophilicity in osseointegration: In-vitro protein-adsorption and blood-interaction studies. J Biomed Mater Res Part A2015:103A:2661–2672.
28 Wennerberg A, Jimbo R, Stübinger S, Obrecht M, Dard M, Berner S. Nanostructures and hydrophilicity influence osseointegration – A biomechanical study in the rabbit tibia. Clin. Oral Impl. Res. 25, 2014, 1041–1050doi: 10.1111/clr.12213
29 Chrcanovic BR, Albrektsson T, Wennerberg A Smoking and dental implants: A systematic review and meta-analysis. J Dent. 2015 May;43(5):487-98
30 ChenY, Man Y Clinical evaluation of SLActive Titaniumzirconium narrow diameter implants for anterior and posterior crowns in smokers and nonsmokers group. Presented at the ITI World Symposium, Basel, May4-6, 2017 Abstract booklet: Clinical Research 045, p18.
31 Hotchkiss KM et al. Novel in vitro comparative model of osteogenic and inflammatory cell response to dental implants. Dent Mater. 2019 Jan;35(1):176-184.
32 Hsu JT, Shen YW, Kuo CW, Wang RT, Fuh LJ, Huang HL. Impacts of 3D bone-to- implant contact and implant diameter on primary stability of dental implant. J Formos Med Assoc. 2017 Aug;116(8):582-590. ; Buser D, Schenk RK, Steinemann S, Fiorellini JP, Fox CH, Stich H. Influence of surface characteristics on bone integration of titanium implants. A histomorphometric study in miniature pigs. J Biomed Mater Res. 1991 Jul;25(7):889-902 ; Smeets R, Stadlinger B, Schwarz F, Beck-Broichsitter B, Jung O, Precht C, Kloss F, Gröbe A, Heiland M, Ebker T. Impact of Dental Implant Surface Modifications on Osseointegration. Biomed Res Int. 2016;2016:6285620. ; Goyal N., Priyanka R. K. Effect of various implant surface treatments on osseointegration – a literature review. Indian Journal of Dental Sciences. 2012;4:154–157